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Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials

Common Side Effects: Nausea (most common, especially during titration), vomiting, diarrhea, constipation, abdominal pain, dyspepsia

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In all trials, subjects taking semaglutide followed a dose-escalation regimen with the aim of minimizing gastrointestinal adverse events common to the class of GLP-1RAs [23]

These effects produce greater reductions in HbA1c and body weight compared with SGLT2is [19, 20]